{"id":109,"date":"2015-08-30T18:06:11","date_gmt":"2015-08-30T10:06:11","guid":{"rendered":"http:\/\/www.srmsap.tcu.edu.tw\/?p=109"},"modified":"2023-02-09T13:58:51","modified_gmt":"2023-02-09T05:58:51","slug":"dr-je-wen-liou-laboratory","status":"publish","type":"post","link":"https:\/\/srmsap.tcu.edu.tw\/?p=109","title":{"rendered":"Biochemistry, Microbiology, Structural Biology and Nanotechnology_Professor Je-Wen Liou"},"content":{"rendered":"

\"\"<\/a>Contact information<\/strong><\/span>
\n<\/a>Professor<\/strong>\u00a0Je-Wen Liou
\n(Ph.D.\/Imperial College London)<\/span><\/span>
\n<\/strong>Department of Biochemistry, School of Medicine
\nTel: 886-3-8565301 ext.2428\/2429
\ne-mail:\u00a0jwliou@mail.tcu.edu.tw<\/a><\/span>
\n<\/a>Lab Web Address:
\nhttp:\/\/www.jwliou.tcu.edu.tw\/index-English.htm<\/strong>
\n<\/a>
\n<\/p>\n

Research Interests<\/h4>\n

Professor Liou is currently working on the development of peptide lead drugs using bioinformatic approaches, biophysical tools, nano-scale imaging techniques, cellular experiments, and model animals. The peptide drugs will be used to treat infections by antibiotic-resistant pathogenic bacteria, inflammations, or complications caused by viral infections, including those by hepatitis C virus and SARS-CoV-2.<\/p>\n

The Best or Representative Publications, within 10 years, Maximum 5.<\/h4>\n
    \n
  1. Hemalatha Mani, Yi-Cheng Chen, Yen-Kai Chen, Wei-Lin Liu, Shih-Yen Lo, Shu-Hsuan Lin, Je-Wen Liou* (2021, Mar). Nanosized Particles Assembled by a Recombinant Virus Protein Are Able to Encapsulate Negatively Charged Molecules and Structured RNA. Polymers, 13(6), 858. (SCI)<\/li>\n
  2. Ming-Chun Chen, Yu-Chao Hsiao, Chun-Chun Chang, Sheng-Feng Pan, Chih-Wen Peng, Ya-Tzu Li, Cheng-Der Liu, Je-Wen Liou*, Hao-Jen Hsu* (2021, Mar). Valine-279 Deletion-Mutation on Arginine Vasopressin Receptor 2 Causes Obstruction in G-Protein Binding Site: A Clinical Nephrogenic Diabetes Insipidus Case and Its Sub-Molecular Pathogenic Analysis. Biomedicines, 9(3), 301. (SCI)<\/li>\n
  3. Chin-Hao Yang, Yi-Cheng Chen, Shih-Yi Peng, Andy Po-Yi Tsai, Tony Jer-Fu Lee, Jui-Hung Yen, Je-Wen Liou* (2018, Oct). An engineered arginine-rich \u03b1- helical antimicrobial peptide exhibits broad-spectrum bactericidal activity against pathogenic bacteria and reduces bacterial infections in mice. Scientific Reports, 8, 14602. (SCI)<\/li>\n
  4. Chun-Chun Chang, Hao-Jen Hsu, Jui-Hung Yen, Shih-Yen Lo, Je-Wen Liou (2017, May). A Sequence in the loop domain of hepatitis C virus E2 protein identified in silico as crucial for the selective binding to human CD81. PLoS One, 12(5): e0177383. (SCI)<\/li>\n
  5. Chih-Lung Shen, Cheng-Der Liu, Ren-In You, Yung-Hao Ching, Jun Liang, Liangru Ke, Ya-Lin Chen, Hong-Chi Chen, Hao-Jen Hsu, Je-Wen Liou, Elliott Kieff, Chih-Wen Peng* (2016, Feb). Ribosome Protein L4 is essential for Epstein\u2013Barr Virus Nuclear Antigen 1 function. Proc. Natl. Acad. Sci. U.S.A., 113(8):2229-2234. (SCI)<\/li>\n<\/ol>\n

    Title and Source of Research Grants<\/h4>\n