Contact information
Nien-Tsung Lin, Ph.D.
Professor
Master program in Biomedical Sciences, School of Medicine
e-mail: ntlin@gms.tcu.edu.tw
Lab Web Address:
http://www.ntlin.tcu.edu.tw/teacher_2.htm
Research Interests
The rapid emerging of antibiotic-resistant bacterial strains becomes a serious problem, and the world is on the edge of "post-antibiotic era". It has been estimated that by 2050, 10 million people will die each year from antimicrobial-resistant infections. Base on “The Enemy of our enemy is our friend”, bacteriophage will be the best candidate to treat multidrug resistant bacteria. Therefore, the current studies in my lab are focus on isolation and characterization novel lytic bacteriophages against pathogenic microbes, and exploring the mechanisms of phage and its host interaction to identify novel targets for drug design as well as provide novel inhibitors for such targets. Another serious problem with Acinetobacter baumannii is the lack of understanding of its virulence factors, which could be used as new and alternative targets to prevent and treat the infections it causes in humans. The overall goal of this multifaceted approach is not only to acquire basic knowledge that deepens our understanding of the pathobiology of this bacterium but also to apply this knowledge to develop new strategies to address the difficulties encountered with the treatment of the infections A. baumannii causes in humans.
Publications within five years:
- Meity Mardiana, Soon-Hian Teh, Ling-Chun Lin, and Nien-Tsung Lin* (2022). Isolation and Characterization of a Novel Siphoviridae Phage, vB_AbaS_TCUP2199, Infecting Multidrug-Resistant Acinetobacter baumannii. Viruses, 14, 1240.
- Rakesh Roy, Ren-In You, Chan-Hua Chang, Chiou-Ying Yang and Nien-Tsung Lin* (2021). Carboxy-Terminal Processing Protease Controls Production of Outer Membrane Vesicles and Biofilm in Acinetobacter baumannii. Microorganisms, 9(6), 1336.
- Md. Shahed-Al-Mahmud,Rakesh Roy,Febri Gunawan Sugiokto,Md. Nazmul Islam,Ming-Der Lin,Ling-Chun Lin, Nien-Tsung Lin* (2021). Phage φAB6-Borne Depolymerase Combats Acinetobacter baumannii Biofilm Formation and Infection. Antibiotics, 10(3), 279.
- Rakesh Roy, Ren-In You, Ming-Der Lin, Nien-Tsung Lin* (2020). Mutation of the Carboxy-Terminal Processing Protease in Acinetobacter baumannii Affects Motility, Leads to Loss of Membrane Integrity, and Reduces Virulence. Pathogens, 9(5):322.
- Yi-Ling Bai, Md. Shahed-Al-Mahmud, Karuppuchamy Selvaprakash, Nien-Tsung Lin*, Yu-Chie Chen*. (2019). Tail fiber protein-immobilized magnetic nanoparticle-based affinity approaches for detection of Acinetobacter baumannii. Anal Chem, 91(15), 10335-10342.
- I-Ming Lee, Feng-Ling Yang, Te-Li Chen, Kuo-Shiang Liao, Chien-Tai Ren, Nien-Tsung Lin, Yu-Pei Chang, Chung-Yi Wu, and Shih-Hsiung Wu. (2018). Pseudaminic acid on exopolysaccharide of Acinetobacter baumannii plays a critical role in phage-assisted preparation of glycoconjugate vaccine with high antigenicity. J Am Chem Soc, 140(28):8639-8643.
- Shih-Yi Peng, Ren-In You, Meng-Jiun Lai, Nien-Tsung Lin, Li-Kuang Chen, and Kai-Chih Chang. (2017). Highly potent antimicrobial modified peptides derived from the Acinetobacter baumannii phage endolysin LysAB2. Sci Rep,7(1):11477.
- Feng-Ling Yang, Tze-Chi Lou, Shu-Chen Kuo, Wan-Ling Wu, Jeffy Chern, Yi-Tzu Lee, Shui-Tsung Chen, Wei Zou, Nien-Tsung Lin, and Shih-Hsiung Wu. (2017). A medically relevant capsular polysaccharide in Acinetobacter baumannii is a potential vaccine candidate. Vaccine, 35(10):1440-1447.
- I-Ming Lee, I-Fan Tu, Feng-Ling Yang, Tzu-Ping Ko, Jiahn-Haur Liao, Nien-Tsung Lin, Chung-Yi Wu, Chien-Tai Ren, Andrew H.-J. Wang, Ching-Ming Chang, Kai-Fa Huang, and Shih-Hsiung Wu. (2017). Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage fAB6 tailspike protein. Sci Rep, 7:42711.