Biochemistry, Microbiology, Structural Biology and Nanotechnology_Professor Je-Wen Liou

Contact information
Professor Je-Wen Liou
(Ph.D./Imperial College London)
Department of Biochemistry, School of Medicine
Tel: 886-3-8565301 ext.2428/2429
e-mail: jwliou@mail.tcu.edu.tw
Lab Web Address:
http://www.jwliou.tcu.edu.tw/index-English.htm

Research Interests

Professor Liou is currently working on the development of peptide lead drugs using bioinformatic approaches, biophysical tools, nano-scale imaging techniques, cellular experiments, and model animals. The peptide drugs will be used to treat infections by antibiotic-resistant pathogenic bacteria, inflammations, or complications caused by viral infections, including those by hepatitis C virus and SARS-CoV-2.

The Best or Representative Publications, within 10 years, Maximum 5.

  1. Hemalatha Mani, Yi-Cheng Chen, Yen-Kai Chen, Wei-Lin Liu, Shih-Yen Lo, Shu-Hsuan Lin, Je-Wen Liou* (2021, Mar). Nanosized Particles Assembled by a Recombinant Virus Protein Are Able to Encapsulate Negatively Charged Molecules and Structured RNA. Polymers, 13(6), 858. (SCI)
  2. Ming-Chun Chen, Yu-Chao Hsiao, Chun-Chun Chang, Sheng-Feng Pan, Chih-Wen Peng, Ya-Tzu Li, Cheng-Der Liu, Je-Wen Liou*, Hao-Jen Hsu* (2021, Mar). Valine-279 Deletion-Mutation on Arginine Vasopressin Receptor 2 Causes Obstruction in G-Protein Binding Site: A Clinical Nephrogenic Diabetes Insipidus Case and Its Sub-Molecular Pathogenic Analysis. Biomedicines, 9(3), 301. (SCI)
  3. Chin-Hao Yang, Yi-Cheng Chen, Shih-Yi Peng, Andy Po-Yi Tsai, Tony Jer-Fu Lee, Jui-Hung Yen, Je-Wen Liou* (2018, Oct). An engineered arginine-rich α- helical antimicrobial peptide exhibits broad-spectrum bactericidal activity against pathogenic bacteria and reduces bacterial infections in mice. Scientific Reports, 8, 14602. (SCI)
  4. Chun-Chun Chang, Hao-Jen Hsu, Jui-Hung Yen, Shih-Yen Lo, Je-Wen Liou (2017, May). A Sequence in the loop domain of hepatitis C virus E2 protein identified in silico as crucial for the selective binding to human CD81. PLoS One, 12(5): e0177383. (SCI)
  5. Chih-Lung Shen, Cheng-Der Liu, Ren-In You, Yung-Hao Ching, Jun Liang, Liangru Ke, Ya-Lin Chen, Hong-Chi Chen, Hao-Jen Hsu, Je-Wen Liou, Elliott Kieff, Chih-Wen Peng* (2016, Feb). Ribosome Protein L4 is essential for Epstein–Barr Virus Nuclear Antigen 1 function. Proc. Natl. Acad. Sci. U.S.A., 113(8):2229-2234. (SCI)

Title and Source of Research Grants

  • Title: In vitro and in vivo experimental validations of algorithmic designed functional peptides
    Source: Ministry of Science and Technology, Taiwan
  • Title: Translational Medicine Research on Nephrogenic Diabetes Insipidus
    Source: Buddhist Compassion Relief Tzu Chi Foundation
  • Title: In search and validations of therapeutics for the treatment of COVID-19: Platform for developing peptide therapeutics targeting COVID-19 related inflammatory storm and secondary bacterial infections
    Source: Collaborative Grant by Tzu Chi Medical Foundation, Tzu Chi University, and Academia Sinica

Publications for recent 5 years 

  1. Chang CC, Hsu HJ, Yen JH, Lo SY, Liou JW*. A Sequence in the loop domain of hepatitis C virus E2 protein identified in silico as crucial for the selective binding to human CD81. PLoS One. 2017. 12(5):e0177383. (SCI)
  2. Chuang CJ, Liu CD, Patil RA, Wu CC, Chang YC, Peng CW, Chao TK, Liou JW, Liou Y, Ma YR. Impact of cuticle photoluminescence on the color morphism of a male damselfly Ischnura senegalensis (Rambur, 1842). Sci Rep. 2016. 6:38051. (SCI)
  3. Tseng CC, Tsai YH, Hu A, Liou JW, Chang KC, Chang HH. Altered susceptibility to the bactericidal effect of photocatalytic oxidation by TiO2 is related to colistin resistance development in Acinetobacter baumannii. Appl Microbiol Biotechnol. 2016. 100(19):8549-61. (SCI)
  4. Chen HY, Nieh HM, Yang MF, Chou YK, Chung JH, Liou JW. Implementation of a Low-Cost Automated LED Photometer for Enzymatic Reaction Detection to Teach Basic Bioelectronics Technologies in Vocational High Schools. IEEE Transactions on Education. 2016. 59(3): 194-201. (SCI)
  5. Shen CL, Liu CD, You RI, Ching YH, Liang J, Ke L, Chen YL, Chen HC, Hsu HJ, Liou JW, Kieff E, Peng CW. Ribosome Protein L4 is essential for Epstein-Barr Virus Nuclear Antigen 1 function. Proc Natl Acad Sci U S A. 2016. 113(8):2229-34. (SCI)
  6. Jiang SJ, Liou JW, Chang CC, Chung Y, Lin LF, Hsu HJ. Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1. Sci Rep. 2015. 5:18638. (SCI)
  7. Hsu SY, Liou JW, Cheng TL, Peng SY, Lin CC, Chu YY, Luo WC, Huang ZK, Jiang SJ. beta-Naphthoflavone protects from peritonitis by reducing TNF-alpha-induced endothelial cell activation. Pharmacol Res. 2015. 102:192-9. (SCI)
  8. Liou JW, Hung YJ, Yang CH, Chen YC. The Antimicrobial Activity of Gramicidin A Is Associated with Hydroxyl Radical Formation. PLoS One. 2015. 10(1):e0117065 (SCI)
  9. Liou JW, Chang FT, Chung Y, Chen WY, Fischer WB, Hsu HJ. In Silico Analysis Reveals Sequential Interactions and Protein Conformational Changes during the Binding of Chemokine CXCL-8 to Its Receptor CXCR1. PLoS One. 2014. 9(4):e94178. (SCI)
  10. Chang KC, Cheng SJ, Chen YC, Huang HR, Liou JW*. Nanoscopic analysis on pH induced morphological changes of flagella in Escherichia coli. J Microbiol Immunol Infect. 2013. 46(6): 405-412. (SCI)